Ionis Pharmaceuticals, Inc. discovers and develops RNA-targeted therapeutics in the United States. The company offers SPINRAZA for spinal muscular atrophy (SMA) in pediatric and adult patients; TEGSEDI, an injection for the treatment of polyneuropathy of hereditary transthyretin-mediated amyloidosis in adults; and WAYLIVRA, a treatment for familial chylomicronemia syndrome and familial partial lipodystrophy. It is involved in developing neurology products that include Tominersen for Huntington's diseases; Tofersen for amyotrophic lateral sclerosis (ALS); IONIS-MAPTRx for Alzheimer's diseases; IONIS-C9Rx for genetic from ALS; ION859 for Parkinson's disease; and IONIS-DNM2-2.5Rx for centronuclear myopathy. The company is also developing severe and rare disease products, such as AKCEA-TTR-LRx for transthyretin amyloidosis and IONIS-GHR-LRx for acromegaly; IONIS-PKK-LRx for hereditary angioedema; IONIS-TMPRSS6-LRx for beta-thalassemia and iron toxicity; IONIS-ENAC-2.5Rx for cystic fibrosis; and ION357 for retinitis pigmentosa. In addition, its cardio metabolic and renal drugs include AKCEA-APO(a)-LRx and AKCEA-APOCIII-LRx for cardiovascular diseases; AKCEA-ANGPTL3-LRx for cardio metabolic disorders; IONIS-GCGRRx for type 2 diabetes; IONIS-AGT-LRX for the treatment of resistant hyper tension; IONIS-FXI-LRx for clotting disorders; IONIS-AZ4-2.5-LRx for cardiovascular diseases; and ION839 for nonalcoholic steatohepatitis. Further, the company develops products for oncology that include IONIS-AR-2.5Rx and danvatirsen for cancers; IONIS-HBVRx and IONIS-HBV-LRx for hepatitis B virus infection; and IONIS-FB-LRx for compliment meditated disease. It has a collaboration agreement with AstraZeneca; Biogen Inc.; and Roche. Ionis Pharmaceuticals, Inc. was founded in 1989 and is based in Carlsbad, California.

Date	Fund	Action	%
2023/11/07	ARKG	Sell	0.0507
2023/10/31	ARKG	Sell	0.1007
2023/10/30	ARKG	Sell	0.0521
2023/10/19	ARKG	Sell	0.2126
2023/10/18	ARKG	Sell	0.0745
2023/10/17	ARKG	Sell	0.1484
2023/10/13	ARKG	Sell	0.2001
2023/10/12	ARKG	Sell	0.0229
2023/08/08	ARKG	Sell	0.0243
2023/08/07	ARKG	Sell	0.0354
2023/08/04	ARKG	Sell	0.0209
2023/08/03	ARKG	Sell	0.0095
2023/05/09	ARKG	Sell	0.1844
2023/05/08	ARKG	Sell	0.0196
2022/12/02	ARKG	Sell	0.188
2022/12/01	ARKG	Sell	0.0316
2022/11/03	ARKG	Sell	0.3676
2022/11/02	ARKG	Sell	0.0972
2022/10/31	ARKG	Sell	0.0297
2022/10/18	ARKG	Sell	0.0871
2022/07/14	ARKG	Sell	0.0354
2022/07/13	ARKG	Sell	0.0943
2022/07/12	ARKG	Sell	0.1148
2022/07/11	ARKG	Sell	0.0226
2022/07/08	ARKG	Sell	0.0356
2022/07/07	ARKG	Sell	0.0278
2022/07/06	ARKG	Sell	0.0194
2022/07/05	ARKG	Sell	0.2522
2022/06/09	ARKG	Sell	0.0817
2022/06/08	ARKG	Sell	0.1034